Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review
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چکیده
منابع مشابه
All Trans Retinoic Acid (ATRA) induced myositis.
A 5-year-old girl presented with fever, skin and mucosal bleeds, and pallor. Her hemoglobin was 3.6 g/dL, total white cell count 4.5×103/μL and platelet count 13×103/μL. Peripheral smear revealed 30% blasts, confirmed as APML on bone marrow examination. Cytogenetic analysis showed the typical translocation of t(15:17) with 77% of interphase cells expressing PML:RARA gene fusion. Child was start...
متن کاملGene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.
Using cDNA microarrays we determined the gene expression patterns in the human acute promyelocytic leukemia (APL) cell line NB4 during all-trans retinoic acid (ATRA)-induced differentiation. We analyzed the expression of 12,288 genes in the NB4 cells after 12 hours, 24 hours, 48 hours, 72 hours, and 96 hours of ATRA exposure. During this time course, we found 168 up-regulated and more than 179 ...
متن کاملAll-trans-retinoic acid: measurement
A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
متن کاملAll-trans-retinoic acid-induced rhabdomyolysis: a case report
All-trans retinoic acid (ATRA) induced rhabdomyolysis in the induction treatment of acute promyelocytic leukemia (APL) is a very rare complication. However, rhabdomyolysis-related acute renal failure increases the risk of high morbidity and mortality. Here we describe a case of rhabdomyolysis associated with ATRA during the induction therapy in an adult with APL. Clinical implications are discu...
متن کاملInfluence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines.
We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2019
ISSN: 1471-2407
DOI: 10.1186/s12885-019-6081-7